| Cat. No. |
Product Name |
Information |
| PC-50013 |
Quizartinib dihydrochloride
FLT3 inhibitor
|
Quizartinib dihydrochloride (AC220) is a potent, selective, second-generation FLT3 inhibitor with Kd of 1.6 nM, inhibits Wt FLT3 and FLT3-ITD autophosphorylation in MV4-11cell with IC50 of 4.2 and 1.1 nM, respectively. |
| PC-43312 |
Quizartinib
FLT3 inhibitor
|
Quizartinib (AC220) is a potent, selective, second-generation FLT3 inhibitor with Kd of 1.6 nM, inhibits Wt FLT3 and FLT3-ITD autophosphorylation in MV4-11cell with IC50 of 4.2 and 1.1 nM, respectively. |
| PC-63198 |
BDT001
FLT3 inhibitor
|
BDT001 is a first-in-class, non-competitive FLT3 negative allosteric modulator, effectively prevents extracellular cytokine FL binding to FLT3 with IC50 of 11 uM. |
| PC-42981 |
G-749
FLT3 inhibitor
|
Denfivontinib (G-749) is a potent, broad-spetrum FLT-3 inhibitor with IC50 of 0.4 and 0.6 nM against wt FLT-3 and FLT3-D835Y mutant, respectively. |
| PC-63101 |
JH-IX-179
FLT3 inhibitor
|
JH-IX-179 is a novel highly potent and selective type I ATP competitive pan-FLT3 inhibitor with IC50 of 4 and 10 nM for FLT3-ITD and D835Y, respectively. |
| PC-62529 |
HSD1169
FLT3 inhibitor
|
HSD1169 is a potent, dual FLT3/TOPK inhibitor with activity against FLT3-ITD secondary mutations (D835 or F691, Kd=1-5 nM), potently inhibits acute myeloid leukemia cell lines (IC50=5 nM). |
| PC-60368 |
FLT3-IN-5e
FLT3 inhibitor
|
FLT3-IN-5e is a nove potent, selective FLT3 inhibitor with Kd of 3.6 nM, IC50 of <6 nM. |
| PC-42447 |
Tandutinib
FLT3/Kit/PDGFR inhibitor
|
Tandutinib (MLN-518, CT53518) is a potent inhibitor of FLT3, Kit and PDGFR with IC50 of 0.22, 0.17 and 0.2 uM, respectively. |
| PC-43033 |
Gilteritinib
FLT3/AXL inhibitor
|
Gilteritinib (ASP2215) is a potent FLT3/AXL inhibitor with IC50 of 0.73 nM/0.29 nM respectively; also inhibits LTK and ALK (IC50=0.35 nM and 1.2 nM respectively). |
| PC-42536 |
KW-2449
Multikinase inhibitor
|
KW-2449 is a multikinase inhibitor of FLT3/ABL/ABL-T315I/Aurora A/Aurora B with IC50 of 6.6/14/4/48/48 nM respectively. |
| PC-26900 |
FYJ-195
FLT3 inhibitor
|
FYJ-195 is a highly potent type II FLT3 inhibitor with IC50 of 2.03 nM for FLT3-ITD, overcomes recalcitrant gatekeeper F691L and activation loop D835V/Y variants. |
| PC-26471 |
FLC-8
FLT3 inhibitor
|
FLC-8 is a potent, selective and covalent FLT3 inhibitor with IC50 of 10.2 nM, 11.6 nM and 24.1 nM for FLT3-WT, FLT3 G697R and FLT3 N676D respectively. |
