| Cat. No. |
Product Name |
Information |
| PC-43312 |
Quizartinib
FLT3 inhibitor
|
Quizartinib (AC220) is a potent, selective, second-generation FLT3 inhibitor with Kd of 1.6 nM, inhibits Wt FLT3 and FLT3-ITD autophosphorylation in MV4-11cell with IC50 of 4.2 and 1.1 nM, respectively. |
| PC-63198 |
BDT001
FLT3 inhibitor
|
BDT001 is a first-in-class, non-competitive FLT3 negative allosteric modulator, effectively prevents extracellular cytokine FL binding to FLT3 with IC50 of 11 uM. |
| PC-42981 |
G-749
FLT3 inhibitor
|
Denfivontinib (G-749) is a potent, broad-spetrum FLT-3 inhibitor with IC50 of 0.4 and 0.6 nM against wt FLT-3 and FLT3-D835Y mutant, respectively. |
| PC-63101 |
JH-IX-179
FLT3 inhibitor
|
JH-IX-179 is a novel highly potent and selective type I ATP competitive pan-FLT3 inhibitor with IC50 of 4 and 10 nM for FLT3-ITD and D835Y, respectively. |
| PC-62529 |
HSD1169
FLT3 inhibitor
|
HSD1169 is a potent, dual FLT3/TOPK inhibitor with activity against FLT3-ITD secondary mutations (D835 or F691, Kd=1-5 nM), potently inhibits acute myeloid leukemia cell lines (IC50=5 nM). |
| PC-60368 |
FLT3-IN-5e
FLT3 inhibitor
|
FLT3-IN-5e is a nove potent, selective FLT3 inhibitor with Kd of 3.6 nM, IC50 of <6 nM. |
| PC-42447 |
Tandutinib
FLT3/Kit/PDGFR inhibitor
|
Tandutinib (MLN-518, CT53518) is a potent inhibitor of FLT3, Kit and PDGFR with IC50 of 0.22, 0.17 and 0.2 uM, respectively. |
| PC-43033 |
Gilteritinib
FLT3/AXL inhibitor
|
Gilteritinib (ASP2215) is a potent FLT3/AXL inhibitor with IC50 of 0.73 nM/0.29 nM respectively; also inhibits LTK and ALK (IC50=0.35 nM and 1.2 nM respectively). |
| PC-42536 |
KW-2449
Multikinase inhibitor
|
KW-2449 is a multikinase inhibitor of FLT3/ABL/ABL-T315I/Aurora A/Aurora B with IC50 of 6.6/14/4/48/48 nM respectively. |
| PC-25801 |
LT-540-717
FLT3 inhibitor
|
LT-540-717 is a potent, selective and orally available FLT3 inhibitor with IC50 of 0.62 nM, inhibits FLT3 mutations FLT3 (ITD), FLT3 (D835V), FLT3 (ITD, D835V), FLT3 (ITD, F69L) with IC50 of 18.22, 1.54, 0.58 and 1.61 nM, respectively. |
| PC-25800 |
FN-1501
FLT3 inhibitor
|
FN-1501 (FN1501) is a potent FLT3 and CDK inhibitor with IC50 of 0.27 nM, 2.47 nM, 0.85 nM and 1.96 nM for FLT3, CDK2/cyclin A, CDK4/cyclin D1, and CDK6/cyclin D1 respectively, induces collapsin response mediator protein 2 (CRMP2) dephosphorylation in breast cancer cells. |
| PC-25422 |
PLM-101 hydrochloride
FLT3/RET inhibitor
|
PLM-101 hydrochloride is a synthetic derivative of indirubin and potent, dual FLT3/RET inhibitor with IC50 of 0.565 nM and 0.849 nM for FLT3-ITD and RET kinase respectively. |
