| Cat. No. |
Product Name |
Information |
| PC-43033 |
Gilteritinib
FLT3/AXL inhibitor
|
Gilteritinib (ASP2215) is a potent FLT3/AXL inhibitor with IC50 of 0.73 nM/0.29 nM respectively; also inhibits LTK and ALK (IC50=0.35 nM and 1.2 nM respectively). |
| PC-42536 |
KW-2449
Multikinase inhibitor
|
KW-2449 is a multikinase inhibitor of FLT3/ABL/ABL-T315I/Aurora A/Aurora B with IC50 of 6.6/14/4/48/48 nM respectively. |
| PC-23629 |
Danatinib
FLT3 inhibitor
|
Danatinib is a potent and selective FLT3 inhibitor with IC50 of 3 nM, overcomes acquired resistance and shows effective inhibition against FLT3-ITD and/or FLT3-TKD mutations. |
| PC-23628 |
SILA-123
FLT3 inhibitor
|
SILA-123 (SILA123) is a potent, selective type II FLT3 inhibitor with IC50 of 2.1 nM and 1.0 nM for FLT3-WT and FLT3-ITD respectively. |
| PC-23460 |
SKLB1028
EGFR/FLT3/Abl inhibitor
|
SKLB1028 (Ruserontinib) is a potent, oral multikinase inhibitor of EGFR, FLT3 and Abl with IC50 of 55 nM (FLT3), potently inhibits the wild-type and L858R-mutant EGFR with IC50 values of 31 nM and 4 nM, respectively. |
| PC-22539 |
HSN748
FLT3 inhibitor
|
HSN748 is potent, selective, type II inhibitor of FLT3 (Kd=0.15 nM) and FLT3 mutants (FLT3 D835Y, KD=1.4 nM), shows potently effective against drug-resistant secondary mutations of FLT3. |
| PC-21565 |
TSN084
Multikinase inhibitor
|
TSN084 (TSN 084) is a unique small molecule multi-kinase inhibitor of drug-resistant mutations of c-Met, Trks, and Flt3, also inhibits other oncotargets including Axl, DDRs, and CDK8/19. |
| PC-21367 |
FLT3 inhibitor 17
FLT3 inhibitor
|
FLT3 inhibitor 17 is a potent, highly selective FLT3 inhibitor with IC50 of 1.2 nM and 1.4 nM for FLT3 WT and FLT3-D835Y, shows low activity against VEGFR, FGFR, PDGFR, c-KIT, and RET. |
| PC-61960 |
HEC-73543
|
HEC-73543 is a novel potent, selective, orally bioavailable FLT3 inhibitor for the treatment of refractory acute myeloid leukemia (AML). |
