FLC-8

Chemical Structure : FLC-8

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货号: PC-26471Not For Human Use, Lab Use Only.

FLC-8 is a potent, selective and covalent FLT3 inhibitor with IC50 of 10.2 nM, 11.6 nM and 24.1 nM for FLT3-WT, FLT3 G697R and FLT3 N676D respectively.

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生物&药学活性

FLC-8 is a potent, selective and covalent FLT3 inhibitor with IC50 of 10.2 nM, 11.6 nM and 24.1 nM for FLT3-WT, FLT3 G697R and FLT3 N676D respectively.
FLC-8 covalently target Cys807, a nucleophilic residue within the FLT3 kinase domain.
FLC-8 suppressed FLT3-mediated STAT5, AKT, and ERK signaling and induced apoptosis in AML cells while maintaining low-nanomolar potency over 72 h.
FLC-8 inhibited MV4-11 xenograft growth (TGI: 136–178% at 10–50 mg/kg) without overt toxicity.

物理化学性质&存储条件

分子量	496.45
分子式	C24H19F3N6O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-(3-(4-(3-Amino-6-methylisoxazolo[5,4-b]pyridin-4-yl)phenyl)ureido)-2-(trifluoromethyl)phenyl)acrylamide

参考文献

1. Wang ZX, et al. J Med Chem. 2026 Apr 3. doi: 10.1021/acs.jmedchem.6c00511.

FLC-8

生物&药学活性

物理化学性质&存储条件

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FLC-8

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物理化学性质&存储条件

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