Quizartinib (AC220) | FLT3 inhibitor | Probechem Biochemicals

Chemical Structure : Quizartinib

CAS No.: 950769-58-1

加入收藏

Quizartinib (AC-220, AC220)

货号: PC-43312Not For Human Use, Lab Use Only.

Quizartinib (AC220) is a potent, selective, second-generation FLT3 inhibitor with Kd of 1.6 nM, inhibits Wt FLT3 and FLT3-ITD autophosphorylation in MV4-11cell with IC50 of 4.2 and 1.1 nM, respectively.

规格	价格	库存
5 mg	￥780	In stock
10 mg	￥1180	In stock
50 mg	￥2580	In stock
100 mg	￥4280	In stock
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

Quizartinib (AC220) is a potent, selective, second-generation FLT3 inhibitor with Kd of 1.6 nM, inhibits Wt FLT3 and FLT3-ITD autophosphorylation in MV4-11cell with IC50 of 4.2 and 1.1 nM, respectively.
Quizartinib (AC220) displays excellent kinase selectivity in a KinomeScan panel of 402 kinase binding assays, also potently inhibits PDGFRA, PDGFRB and RET.
Quizartinib (AC220) inhibits MV4-11 cell proliferarion with IC50 of 0.56 nM, demonstrates antitumor efficacy in the MV4-11 tumor xenograft model.

物理化学性质&存储条件

分子量	560.6672
分子式	C29H32N6O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 33 mg/mL
Chemical Name/SMILES	Urea, N-[5-(1,1-dimethylethyl)-3-isoxazolyl]-N'-[4-[7-[2-(4-morpholinyl)ethoxy]imidazo[2,1-b]benzothiazol-2-yl]phenyl]-

参考文献

1. Zarrinkar PP, et al. Blood. 2009 Oct 1;114(14):2984-92.

2. Chao Q, et al. J Med Chem. 2009 Dec 10;52(23):7808-16.

3. Pratz KW, et al. Blood. 2010 Feb 18;115(7):1425-32.

4. Gunawardane RN, et al. Mol Cancer Ther. 2013 Apr;12(4):438-47.

Quizartinib (AC-220, AC220)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Quizartinib (AC-220, AC220)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.