JH-IX-179 | FLT3 inhibitor | Probechem Biochemicals

Chemical Structure : JH-IX-179

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JH-IX-179 (FLT3 inhibitor)

货号: PC-63101Not For Human Use, Lab Use Only.

JH-IX-179 is a novel highly potent and selective type I ATP competitive pan-FLT3 inhibitor with IC50 of 4 and 10 nM for FLT3-ITD and D835Y, respectively.

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25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

JH-IX-179 is a novel highly potent and selective type I ATP competitive pan-FLT3 inhibitor with IC50 of 4 and 10 nM for FLT3-ITD and D835Y, respectively.
JH-IX-179 exhibits an IC50 of 2 and 11 nM against MOLM-13 and MOLM-14 cell lines, respectively。
JH-IX-179 is extremely potent and selective for FLT3, also has the highest affinity for three constitutively active isoforms of FLT3 (FLT3-ITD, FLT3-N841I, and FLT3-D835V) compared to a panel 456 other kinases。
JH-IX-179 inhibits cell cycle progression (G1 arrest) and induces apoptosis in FLT3-ITD-expressing cells.

物理化学性质&存储条件

分子量	436.519
分子式	C26H24N6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(1-(3-(dimethylamino)propyl)-1H-pyrazol-4-yl)-7-(1H-pyrazol-4-yl)indeno[1,2-b]indol-10(5H)-one

参考文献

1. Hatcher JM, et al. ACS Med Chem Lett. 2016 Mar 8;7(5):476-81.