KW-2449 |CAS:1000669-72-6 Probechem Biochemicals

Chemical Structure : KW-2449

CAS No.: 1000669-72-6

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KW-2449 (KW 2449;KW2449)

货号: PC-42536Not For Human Use, Lab Use Only.

KW-2449 is a multikinase inhibitor of FLT3/ABL/ABL-T315I/Aurora A/Aurora B with IC50 of 6.6/14/4/48/48 nM respectively.

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10 mg	￥680	In stock
25 mg	￥1180	In stock
50 mg	￥1880	In stock
100 mg		Get quote

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生物&药学活性

KW-2449 is a multikinase inhibitor of FLT3/ABL/ABL-T315I/Aurora A/Aurora B with IC50 of 6.6/14/4/48/48 nM respectively.
KW-2449 has little effect on PDGFRβ, IGF-1R, EGFR, and various serine/threonine kinases at 1 uM.
KW-2449 exhibits potent growth inhibitory effects on leukemia cells with FLT3 mutations, resulting in the down-regulation of phosphorylated-FLT3/STAT5, G1 arrest, and apoptosis; orally active.

物理化学性质&存储条件

分子量	332.399
分子式	C20H20N4O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Methanone, [4-[2-(1H-indazol-3-yl)ethenyl]phenyl]-1-piperazinyl-

参考文献

1. Shiotsu Y, et al. Blood. 2009 Aug 20;114(8):1607-17.

2. Nguyen T, et al. Clin Cancer Res. 2011 May 15;17(10):3219-32.

3. Pratz KW, et al. Blood. 2009 Apr 23;113(17):3938-46.

KW-2449 (KW 2449;KW2449)

生物&药学活性

物理化学性质&存储条件

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KW-2449 (KW 2449;KW2449)

生物&药学活性

物理化学性质&存储条件

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