| Cat. No. |
Product Name |
Information |
| PC-25421 |
PLM-101
FLT3/RET inhibitor
|
PLM-101 is a synthetic derivative of indirubin and potent, dual FLT3/RET inhibitor with IC50 of 0.565 nM and 0.849 nM for FLT3-ITD and RET kinase respectively.
PLM-101 inhibits the proliferation of Ba/F3 cells expressing FLT3-ITD-mutant kinases at the nanomolar (nM) concentration levels. |
| PC-24959 |
CCT241736
FLT3/Aurora kinase inhibitor
|
CCT241736 (Mobinitinib) is a potent, orally bioavailable dual FLT3/Aurora kinase inhibitor with binding Kd of 7.5/48/6.2/38/14 nM for Aurora-A/Aurora-B/FLT3 WT/FLT3-ITD/FLT3(D835Y) respectively. |
| PC-24406 |
Clifutinib besylate
FLT3-ITD inhibitor
|
Clifutinib besylate (HEC73543) is potent, selective FLT3-ITD (internal tandem duplication mutations of FLT3) inhibitor with biochemical IC50 of 15.1 nM, exhibits significant antiproliferative activity against Ba/F3-FLT3-ITD cells with IC50 of 0.9 nM. |
| PC-23629 |
Danatinib
FLT3 inhibitor
|
Danatinib is a potent and selective FLT3 inhibitor with IC50 of 3 nM, overcomes acquired resistance and shows effective inhibition against FLT3-ITD and/or FLT3-TKD mutations. |
| PC-23628 |
SILA-123
FLT3 inhibitor
|
SILA-123 (SILA123) is a potent, selective type II FLT3 inhibitor with IC50 of 2.1 nM and 1.0 nM for FLT3-WT and FLT3-ITD respectively. |
| PC-21367 |
FLT3 inhibitor 17
FLT3 inhibitor
|
FLT3 inhibitor 17 is a potent, highly selective FLT3 inhibitor with IC50 of 1.2 nM and 1.4 nM for FLT3 WT and FLT3-D835Y, shows low activity against VEGFR, FGFR, PDGFR, c-KIT, and RET. |
