| Cat. No. |
Product Name |
Information |
| PC-26046 |
AMG 925
CDK4/FLT3 inhibitor
|
AMG 925 (AMG925, AMG-925) is a potent and orally bioavailable dual inhibitor of CDK4 and FLT3 with IC50 of 3 nM and 1 nM for CDK4/Cyclin D1 and FLT3 respectively. |
| PC-25801 |
LT-540-717
FLT3 inhibitor
|
LT-540-717 is a potent, selective and orally available FLT3 inhibitor with IC50 of 0.62 nM, inhibits FLT3 mutations FLT3 (ITD), FLT3 (D835V), FLT3 (ITD, D835V), FLT3 (ITD, F69L) with IC50 of 18.22, 1.54, 0.58 and 1.61 nM, respectively. |
| PC-25800 |
FN-1501
FLT3 inhibitor
|
FN-1501 (FN1501) is a potent FLT3 and CDK inhibitor with IC50 of 0.27 nM, 2.47 nM, 0.85 nM and 1.96 nM for FLT3, CDK2/cyclin A, CDK4/cyclin D1, and CDK6/cyclin D1 respectively, induces collapsin response mediator protein 2 (CRMP2) dephosphorylation in breast cancer cells. |
| PC-25422 |
PLM-101 hydrochloride
FLT3/RET inhibitor
|
PLM-101 hydrochloride is a synthetic derivative of indirubin and potent, dual FLT3/RET inhibitor with IC50 of 0.565 nM and 0.849 nM for FLT3-ITD and RET kinase respectively. |
| PC-25421 |
PLM-101
FLT3/RET inhibitor
|
PLM-101 is a synthetic derivative of indirubin and potent, dual FLT3/RET inhibitor with IC50 of 0.565 nM and 0.849 nM for FLT3-ITD and RET kinase respectively.
PLM-101 inhibits the proliferation of Ba/F3 cells expressing FLT3-ITD-mutant kinases at the nanomolar (nM) concentration levels. |
| PC-24959 |
CCT241736
FLT3/Aurora kinase inhibitor
|
CCT241736 (Mobinitinib) is a potent, orally bioavailable dual FLT3/Aurora kinase inhibitor with binding Kd of 7.5/48/6.2/38/14 nM for Aurora-A/Aurora-B/FLT3 WT/FLT3-ITD/FLT3(D835Y) respectively. |
| PC-24406 |
Clifutinib besylate
FLT3-ITD inhibitor
|
Clifutinib besylate (HEC73543) is potent, selective FLT3-ITD (internal tandem duplication mutations of FLT3) inhibitor with biochemical IC50 of 15.1 nM, exhibits significant antiproliferative activity against Ba/F3-FLT3-ITD cells with IC50 of 0.9 nM. |
| PC-23629 |
Danatinib
FLT3 inhibitor
|
Danatinib is a potent and selective FLT3 inhibitor with IC50 of 3 nM, overcomes acquired resistance and shows effective inhibition against FLT3-ITD and/or FLT3-TKD mutations. |
| PC-21367 |
FLT3 inhibitor 17
FLT3 inhibitor
|
FLT3 inhibitor 17 is a potent, highly selective FLT3 inhibitor with IC50 of 1.2 nM and 1.4 nM for FLT3 WT and FLT3-D835Y, shows low activity against VEGFR, FGFR, PDGFR, c-KIT, and RET. |
