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首页-小分子抑制剂&激动剂-Tyrosine Kinase-FLT3-FN-1501
FN-1501

Chemical Structure : FN-1501

CAS No.: 1429515-59-2

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FN-1501 (FN1501)

货号: PC-25800Not For Human Use, Lab Use Only.

FN-1501 (FN1501) is a potent FLT3 and CDK inhibitor with IC50 of 0.27 nM, 2.47 nM, 0.85 nM and 1.96 nM for FLT3, CDK2/cyclin A, CDK4/cyclin D1, and CDK6/cyclin D1 respectively, induces collapsin response mediator protein 2 (CRMP2) dephosphorylation in breast cancer cells.

规格 价格 库存 数量
5 mg ￥1280 In stock
10 mg ￥1980 In stock
25 mg ￥3580 In stock
50 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

FN-1501 (FN1501) is a potent FLT3 and CDK inhibitor with IC50 of 0.27 nM, 2.47 nM, 0.85 nM and 1.96 nM for FLT3, CDK2/cyclin A, CDK4/cyclin D1, and CDK6/cyclin D1 respectively, induces collapsin response mediator protein 2 (CRMP2) dephosphorylation in breast cancer cells.
FN-1501 exhibits potent inhibitory activities on all 60 cancer cell lines with GI50 of <0.5 uM.
FN-1501 shows significant antiproliferative activities against MV4-11 cells with IC50 of 8 nM.
FN-1501 (0-1 uM) significantly decreased the phosphorylation of FLT3 and that of its downstream mediators STAT5, ERK, and AKT in MV4-11 cells.
FN-1501 at 15 (mg/kg)/d induced tumor regression MV4-11-xenograft model.

物理化学性质&存储条件

分子量 431.50
分子式 C22H25N9O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-N-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-1H-pyrazole-3-carboxamide

参考文献

1. Wang Y, et al. J Med Chem. 2018 Feb 22;61(4):1499-1518.

2. Lin B, et al. Oncogene. 2020 Sep;39(37):6024-6040.

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