BDT001 | FLT3 inhibitor | Probechem Biochemicals

Chemical Structure : BDT001

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BDT001 (BDT 001, BDT-001)

货号: PC-63198Not For Human Use, Lab Use Only.

BDT001 is a first-in-class, non-competitive FLT3 negative allosteric modulator, effectively prevents extracellular cytokine FL binding to FLT3 with IC50 of 11 uM.

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生物&药学活性

BDT001 is a first-in-class, non-competitive FLT3 negative allosteric modulator, effectively prevents extracellular cytokine FL binding to FLT3 with IC50 of 11 uM.
BDT001 inhibits FL-induced FLT3 phosphorylation in leukemia-derived RS4-11 cells with IC50 of 18-24 uM.
BDT001 reverses the potentiation by FL with a maximal effect at 1 uM, with no effect on capsaicin-induced TRPV1 activation nor basal Ca2+ in primary cultures of adult DRG neurons.
BDT001 strongly reduces nerve injury-induced sensory hypersensitivity, with no effect on nociception in non-injured animals.

物理化学性质&存储条件

分子量	394.87
分子式	C18H19ClN2O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(5-chloro-2-hydroxyphenyl)-3-(piperidin-1-ylsulfonyl)benzamide

参考文献

1. Rivat C, et al. Nat Commun. 2018 Mar 12;9(1):1042.

BDT001 (BDT 001, BDT-001)

生物&药学活性

物理化学性质&存储条件

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BDT001 (BDT 001, BDT-001)

生物&药学活性

物理化学性质&存储条件

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