欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-小分子抑制剂&激动剂-Tyrosine Kinase-FLT3-G-749
G-749

Chemical Structure : G-749

CAS No.: 1457983-28-6

加入收藏

G-749 (Denfivontinib, G 749, G749)

货号: PC-42981Not For Human Use, Lab Use Only.

Denfivontinib (G-749) is a potent, broad-spetrum FLT-3 inhibitor with IC50 of 0.4 and 0.6 nM against wt FLT-3 and FLT3-D835Y mutant, respectively.

规格 价格 库存 数量
5 mg ￥580 In stock
10 mg ￥880 In stock
25 mg ￥1480 In stock
50 mg ￥2380 In stock
100 mg Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Denfivontinib (G-749) is a potent, broad-spetrum FLT-3 inhibitor with IC50 of 0.4 and 0.6 nM against wt FLT-3 and FLT3-D835Y mutant, respectively.
G-749 also shows potent and sustained inhibition of the FLT3 mutants including FLT3-ITD, FLT3-ITD/N676D, and FLT3-ITD/F691L in cellular assays.
G-749 also inhibits RTKs Ret, FLT1, Axl, Fms, FGFR-1/3 (IC50=9-30 nM), and Aurora A and B (IC50=6-24 nM) inhibits autophosphorylation of FLT3 with IC50 of <8 nM in FLT3-WT bearing RS4-11 and in FLT3-ITD harboring MV4-11 and Molm-14 cells.
G-749  shows potent antileukemic activity in patient blasts harboring FLT3-ITD, FLT3-TKD, and FLT3-ITD/TKD mutations through inhibition of pFLT3 and pERK1/2 both in vitro and in vivo, overcomes drug resistance of AC220 and/or PKC412.

物理化学性质&存储条件

分子量 521.409
分子式 C25H25BrN6O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: 25 mg/mL
Chemical Name/SMILES

Pyrido[4,3-d]pyrimidin-5(6H)-one, 8-bromo-2-[(1-methyl-4-piperidinyl)amino]-4-[(4-phenoxyphenyl)amino]-

参考文献

1. Lee HK, et al. Blood. 2014 Apr 3;123(14):2209-19.

备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

联系我们 sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

询单

  • *产品名称:
  • *姓名:
  • *邮箱:
  • *公司名称:
  • *询单数量:
  • *国籍:
  • 询单信息: