FLT3-IN-5e |CAS:2093038-25-4 Probechem Biochemicals

Chemical Structure : FLT3-IN-5e

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FLT3-IN-5e (FLT-3 inhibitor 5e)

货号: PC-60368Not For Human Use, Lab Use Only.

FLT3-IN-5e is a nove potent, selective FLT3 inhibitor with Kd of 3.6 nM, IC50 of <6 nM.

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生物&药学活性

FLT3-IN-5e is a nove potent, selective FLT3 inhibitor with Kd of 3.6 nM, IC50 of <6 nM.
FLT3-IN-5e has high potentcy against mutant FLT3 D835H, D835V, D835Y, ITD-D835V, ITD-F691L, K663Q, N841I, and R834Q (Kd=0.36-82 nM).
FLT3-IN-5e shows weak (8-fold selectivity) activity for PDGFRB (28 nM) and the JAK1 JH2 domain (28 nM).
FLT3-IN-5e possesses growth inhibitory potencies against MOLM13 FLT3-ITD and MOLM13 FLT3-ITD/D835Y cells.

物理化学性质&存储条件

分子量	305.385
分子式	C18H19N5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N4-Isopropyl-N2-(3-(pyridin-3-yl)phenyl)pyrimidine-2,4-diamine

参考文献

1. Jarusiewicz JA, et al. ACS Omega. 2017 May 31;2(5):1985-2009.

FLT3-IN-5e (FLT-3 inhibitor 5e)

生物&药学活性

物理化学性质&存储条件

参考文献

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FLT3-IN-5e (FLT-3 inhibitor 5e)

生物&药学活性

物理化学性质&存储条件

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