HSD1169 | FLT3 inhibitor | Probechem Biochemicals

Chemical Structure : HSD1169

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HSD1169 (HSD-1169)

货号: PC-62529Not For Human Use, Lab Use Only.

HSD1169 is a potent, dual FLT3/TOPK inhibitor with activity against FLT3-ITD secondary mutations (D835 or F691, Kd=1-5 nM), potently inhibits acute myeloid leukemia cell lines (IC50=5 nM).

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生物&药学活性

HSD1169 is a potent, dual FLT3/TOPK inhibitor with activity against FLT3-ITD secondary mutations (D835 or F691, Kd=1-5 nM), potently inhibits acute myeloid leukemia cell lines (IC50=5 nM).
HSD1169 inhibits TOPK with IC50 of 21 nM; is active against MV4-11 and Molm-14 (FLT3-ITD cell lines) but not NOMO-1 or HL60 (FLT3-WT cell lines).
HSD1169 is also active against sorafenib-resistant Molm13-res cell line (containing FLT3-ITD/D835Y).

物理化学性质&存储条件

分子量	357.34
分子式	C18H14F3N5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	7-(3-(trifluoromethyl)-1H-pyrazol-4-yl)-8,9,10,11-tetrahydro-2H-pyrazolo[4,3-a]phenanthridine

参考文献

1. Dayal N, et al. Future Med Chem. 2018 Feb 13. doi: 10.4155/fmc-2017-0298.

HSD1169 (HSD-1169)

生物&药学活性

物理化学性质&存储条件

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HSD1169 (HSD-1169)

生物&药学活性

物理化学性质&存储条件

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