| Cat. No. |
Product Name |
Information |
| PC-21722 |
Evocalcet
CaSR agonist
|
Evocalcet (MT-4580/KHK7580) is a calcimimetic agent and next-generation, oral allosteric CaSR agonist with EC50 of 93 nM (human CaSR). |
| PC-21721 |
Compound 54149
CaSR agonist
|
Compound 54149 is novel positive allosteric modulator (PAM) of calcium sensing receptor (CaSR) with EC50 of 41 nM. |
| PC-20137 |
(S)-AC-265347
CaSR agonist
|
(S)-AC-265347 is a potent, selective CaSR agonist and positive allosteric modulator (ago-PAM), 10- to 20-fold more potent than (R)-AC-265347. |
| PC-20136 |
AC265347
CaSR agonist
|
AC-265347 (AC265347) is a potent, selective CaSR agonist and positive allosteric modulator (ago-PAM), activates CaSR signaling in cellular proliferation and phosphatidylinositol (PI) hydrolysis assays with potencies of 30 and 10 nM, respectively. |
| PC-35260 |
GSK3004774
CaSR agonist
|
GSK3004774 (GSK-3004774) is a potent, nonabsorbable, gastrointestinally-restricted agonist agonist of calcium-sensing receptor (CaSR) with pEC50 of 7.3. |
| PC-63560 |
Velcalcetide
CaSR agonist
|
Velcalcetide (AMG-416, Velcalcetide, Etelcalcetide, KAI-4169) is a potent, peptide agonist of CaSR, dose-dependenty increases IP1 accumulation with EC50 of 25 uM in cell based assays. |
| PC-62909 |
Tecalcet
CaSR modulator
|
Tecalcet (R-568, NPS R-568, KRN-568, NPS-568) is a calcimimetic acting agent and potent, selective positive allosteric modulator (agonist) of CaSR. |
| PC-62908 |
Tecalcet hydrochloride
CaSR modulator
|
Tecalcet (R-568; NPS R-568; KRN-568; NPS-568) is a calcimimetic acting agent and potent, selective positive allosteric modulator (agonist) of CaSR. |
| PC-62905 |
Calhex-231
CaSR modulator
|
Calhex-231 is a potent negative allosteric modulator of CaSR that blocks calcium-mediated activation with IC50 of 0.39 uM. |
| PC-61506 |
Ronacaleret hydrochloride
CaSR modulator
|
Ronacaleret (SB751689) hydrochloride is a potent calcium sensing receptor (CaSR) negative allosteric modulator with IC50 of 146 nM for hCaSR. |
| PC-61505 |
Ronacaleret
CaSR modulator
|
Ronacaleret (SB751689) is a potent calcium sensing receptor (CaSR) negative allosteric modulator with IC50 of 146 nM for hCaSR. |
| PC-61402 |
Upacicalcet
CaSR modulator
|
Upacicalcet is a novel positive allosteric modulator of the calcium-sensing receptor (CaSR), a novel secondary hyperparathyroidism drug that targets the amino acid binding site of CaSR. |
