AC-265347 (AC265347) | CaSR agonist | Probechem Biochemicals

Chemical Structure : AC265347

CAS No.: 1253901-26-6

加入收藏

AC265347 (AC-265347)

货号: PC-20136Not For Human Use, Lab Use Only.

AC-265347 (AC265347) is a potent, selective CaSR agonist and positive allosteric modulator (ago-PAM), activates CaSR signaling in cellular proliferation and phosphatidylinositol (PI) hydrolysis assays with potencies of 30 and 10 nM, respectively.

规格	价格	库存
5 mg	￥1180	In stock
10 mg	￥1880	In stock
25 mg	￥3280	In stock
50 mg	￥5280	In stock
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

AC-265347 (AC265347) is a potent, selective CaSR agonist and positive allosteric modulator (ago-PAM), activates CaSR signaling in cellular proliferation and phosphatidylinositol (PI) hydrolysis assays with potencies of 30 and 10 nM, respectively.
AC-265347 significantly stimulates greater responses than Cinacalcet or Calindol at each of four loss-of-function human polymorphic CaSR variants, and does not inhibit the CYP2D6 cytochrome P450 isozyme。
AC-265347 reduces serum parathyroid hormone (PTH) in rats, also reduces plasma ionizable calcium ([Ca(2+)](o)).

物理化学性质&存储条件

分子量	283.39
分子式	C17H17NOS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-Benzothiazol-2-yl-1-(2,4-dimethyl-phenyl)-ethanol

参考文献

1. Ma JN, et al. J Pharmacol Exp Ther. 2011 Apr;337(1):275-84.

2. Cook AE, et al. Br J Pharmacol. 2015 Jan;172(1):185-200.

AC265347 (AC-265347)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

AC265347 (AC-265347)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.