Velcalcetide |CAS:1262780-97-1 Probechem Biochemicals

Chemical Structure : Velcalcetide

CAS No.: 1262780-97-1

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Velcalcetide (AMG-416;AMG416;Etelcalcetide;KAI-4169)

货号: PC-63560Not For Human Use, Lab Use Only.

Velcalcetide (AMG-416, Velcalcetide, Etelcalcetide, KAI-4169) is a potent, peptide agonist of CaSR, dose-dependenty increases IP1 accumulation with EC50 of 25 uM in cell based assays.

规格	价格	库存
10 mg	￥1280	In stock
25 mg	￥2180	In stock
50 mg	￥3780	In stock
100 mg		Get quote

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生物&药学活性

Velcalcetide (AMG-416, Velcalcetide, Etelcalcetide, KAI-4169) is a potent, peptide agonist of CaSR, dose-dependenty increases IP1 accumulation with EC50 of 25 uM in cell based assays.
Velcalcetide reduces parathyroid hormone (PTH) levels and corresponding decreases serum calcium, regardless of the baseline level of PTH in vivo.

物理化学性质&存储条件

分子量	1048.259
分子式	C38H73N21O10S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	S-(((S)-2-acetamido-3-(((R)-1-(((R)-1-(((R)-1-(((R)-1-(((R)-1-(((R)-1-amino-5-guanidino-1-oxopentan-2-yl)amino)-1-oxopropan-2-yl)amino)-5-guanidino-1-oxopentan-2-yl)amino)-5-guanidino-1-oxopentan-2-yl)amino)-5-guanidino-1-oxopentan-2-yl)amino)-1-oxopropan

参考文献

1. Walter S, et al. J Pharmacol Exp Ther. 2013 Aug;346(2):229-40.

2. Martin KJ, et al. Kidney Int. 2014 Jan;85(1):191-7.

3. Walter S, et al. BMC Nephrol. 2014 May 19;15:81.

4. Martin KJ, et al. Nephrol Dial Transplant. 2014 Feb;29(2):385-92.

Velcalcetide (AMG-416;AMG416;Etelcalcetide;KAI-4169)

生物&药学活性

物理化学性质&存储条件

参考文献

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Velcalcetide (AMG-416;AMG416;Etelcalcetide;KAI-4169)

生物&药学活性

物理化学性质&存储条件

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