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首页-小分子抑制剂&激动剂-GPCR-Calcium-sensing Receptor (CaSR)-Ronacaleret hydrochloride
Ronacaleret hydrochloride

Chemical Structure : Ronacaleret hydrochloride

CAS No.: 702686-96-2

Ronacaleret hydrochloride (SB-751689 hydrochloride)

货号: PC-61506Not For Human Use, Lab Use Only.

Ronacaleret (SB751689) hydrochloride is a potent calcium sensing receptor (CaSR) negative allosteric modulator with IC50 of 146 nM for hCaSR.

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10 mg ¥7880 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Ronacaleret (SB751689) hydrochloride is a potent calcium sensing receptor (CaSR) negative allosteric modulator with IC50 of 146 nM for hCaSR.
Ronacaleret  stimulates parathyroid hormone (PTH) release and increases bone formation markers.
Ronacaleret  act as an effective oral anabolic agent to enhance fracture healing.

物理化学性质&存储条件

分子量 483.98
分子式 C25H32ClF2NO4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

3-[3-[(2R)-3-[[1-(2,3-dihydro-1H-inden-2-yl)-2-methylpropan-2-yl]amino]-2-hydroxypropoxy]-4,5-difluorophenyl]propanoic acid hydrochloride

参考文献

1. Balan G, et al. Bioorg Med Chem Lett. 2009 Jun 15;19(12):3328-32.

2. Fitzpatrick LA, et al. J Clin Endocrinol Metab. 2011 Aug;96(8):2441-9.

3. Fitzpatrick LA, et al. Bone. 2011 Oct;49(4):845-52.

4. Caltabiano S, et al. Bone. 2013 Sep;56(1):154-62.

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