Tecalcet hydrochloride |CAS:177172-49-5 Probechem Biochemicals

Chemical Structure : Tecalcet hydrochloride

CAS No.: 177172-49-5

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Tecalcet hydrochloride (R-568;NPS R-568;KRN-568;NPS-568)

货号: PC-62908Not For Human Use, Lab Use Only.

Tecalcet (R-568; NPS R-568; KRN-568; NPS-568) is a calcimimetic acting agent and potent, selective positive allosteric modulator (agonist) of CaSR.

规格	价格	库存
5 mg	￥1780	In stock
10 mg	￥2880	In stock
25 mg	￥4280	In stock
100 mg		Get quote

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生物&药学活性

Tecalcet (R-568;NPS R-568;KRN-568;NPS-568) is a calcimimetic acting agent and potent, selective positive allosteric modulator (agonist) of CaSR.
Tecalcet (R-568) potentiates the effects of extracellular Ca2+ on [Ca2+]i and PTH secretion without effect in the absence of extracellular Ca2+, does not affect responses elicited by the homologous mGluRs; prevents parathyroid hyperplasia in rats with severe secondary hyperparathyroidism.

物理化学性质&存储条件

分子量	340.288
分子式	C18H23Cl2NO
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-chloro-N-[(1R)-1-(3-methoxyphenyl)ethyl]-benzenepropanamine, monohydrochloride

参考文献

1. Wada M, et al. J Clin Invest. 1997 Dec 15;100(12):2977-83., et al.

2. Nemeth EF, et al. Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):4040-5.

3. Wada M, et al. Kidney Int. 2000 Jan;57(1):50-8.

4. Hammerland LG, et al. Mol Pharmacol. 1998 Jun;53(6):1083-8.

Tecalcet hydrochloride (R-568;NPS R-568;KRN-568;NPS-568)

生物&药学活性

物理化学性质&存储条件

参考文献

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Tecalcet hydrochloride (R-568;NPS R-568;KRN-568;NPS-568)

生物&药学活性

物理化学性质&存储条件

参考文献

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