Evocalcet (MT-4580/KHK7580) | CaSR agonist | Probechem Biochemicals

Chemical Structure : Evocalcet

CAS No.: 870964-67-3

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Evocalcet (KHK7580, KHK-7580, MT-4580)

货号: PC-21722Not For Human Use, Lab Use Only.

Evocalcet (MT-4580/KHK7580) is a calcimimetic agent and next-generation, oral allosteric CaSR agonist with EC50 of 93 nM (human CaSR).

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10 mg	￥780	In stock
25 mg	￥1280	In stock
50 mg	￥1980	In stock
100 mg	￥3280	In stock
250 mg		Get quote

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生物&药学活性

Evocalcet (MT-4580/KHK7580) is a calcimimetic agent and next-generation, oral allosteric CaSR agonist with EC50 of 93 nM (human CaSR).
Evocalcet (MT-4580/KHK7580) exhibits strong inhibition of rat PTH production with IC50 of 30.8 nM.
Oral administration of Evocalcet (MT-4580/KHK7580) efficiently suppressed the secretion of parathyroid hormone (PTH) in rat model of CKD induced by 5/6 nephrectomy.
CYP2D6 inhibition observed in cinacalcet is completely solved in evocalcet.

物理化学性质&存储条件

分子量	374.48
分子式	C24H26N2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(4-((S)-3-(((R)-1-(Naphthalen-1-yl)ethyl)amino)pyrrolidin-1-yl)phenyl)acetic acid

参考文献

1. Kawata T, et al. PLoS One. 2018 Apr 3;13(4):e0195316.

2. Miyazaki H, et al. Bioorg Med Chem Lett. 2018 Jun 15;28(11):2055-2060.

Evocalcet (KHK7580, KHK-7580, MT-4580)

生物&药学活性

物理化学性质&存储条件

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Evocalcet (KHK7580, KHK-7580, MT-4580)

生物&药学活性

物理化学性质&存储条件

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