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首页-小分子抑制剂&激动剂-GPCR-Calcium-sensing Receptor (CaSR)-GSK3004774
GSK3004774

Chemical Structure : GSK3004774

CAS No.: 2138814-32-9

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GSK3004774 (GSK 3004774;GSK-3004774)

货号: PC-35260Not For Human Use, Lab Use Only.

GSK3004774 (GSK-3004774) is a potent, nonabsorbable, gastrointestinally-restricted agonist agonist of calcium-sensing receptor (CaSR) with pEC50 of 7.3.

规格 价格 库存 数量
2 mg ￥3980 In stock
5 mg ￥5980 In stock
10 mg ￥9580 In stock
25 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

GSK3004774 (GSK-3004774) is a potent, nonabsorbable, gastrointestinally-restricted agonist agonist of calcium-sensing receptor (CaSR) with pEC50 of 7.3.
GSK3004774 demonstrates low permeability and low portal drug concentrations and high luminal stability and high fecal drug recovery in vivo DMPK experiments.

物理化学性质&存储条件

分子量 528.697
分子式 C32H40N4O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-(3-(4-((S)-3-(((R)-1-(naphthalen-1-yl)ethyl)amino)pyrrolidin-1-yl)benzamido)propyl)piperidine-4-carboxylic acid

参考文献

1.  Sparks SM, et al. Bioorg Med Chem Lett. 2017 Oct 15;27(20):4673-4677. 

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