| Cat. No. |
Product Name |
Information |
| PC-38308 |
(R)-LMI
CRF1 antagonist
|
(R)-LMI (H2N-R-Leu-Met-Ile-COOH) is a tripeptide analogue of corticotropin-releasing factor (CRF) and CRF antagonist targeting the N-domain of CRF1 receptor. |
| PC-36089 |
SSR125543
CRF1 antagonist
|
SSR125543 (Crinecerfont, SSR-125543) is a potent, nonpeptide, orally active corticotropin-releasing factor (CRF) receptor CRF1 antagonist, shows anxiolytic- and antidepressant-like activities in vivo. . |
| PC-35469 |
Tildacerfont
CRF1 antagonist
|
Tildacerfont (SPR001, LY2371712) is a novel corticotropin releasing factor (CRF) CRF1 receptor antagonist, effectively reduces adrenocorticotropic hormone (ACTH) and adrenal androgen levels. |
| PC-42988 |
NVS-CRF38
CRF1 antagonist
|
NVS-CRF38 is a potent, selective, orally bioavailable corticotropin-releasing factor receptor 1 (CRF1) antagonist with IC50 of 70 nM. |
| PC-61274 |
Antisauvagine-30
CRF2 antagonist
|
Antisauvagine-30 is a potent, selective and competitive corticotropin-releasing factor CRF2 receptor antagonist with Ki of 1.4 nM, 100-fold selectiivity over CRF1. |
| PC-61269 |
Pexacerfont
CRF1 inhibitor
|
Pexacerfont (BMS562086, DPC-A69448) is a potent, selective and orally active CRF1 receptor antagonist with IC50 of 6.1 nM, >1,000-fold selectivity over CRF-binding protein and biogenic amine receptors. |
| PC-61268 |
CP 376395
CRF1 antagonist
|
CP376395 is a potent, selective and orally active CRF1 receptor antagonist with Ki of 12 nM, shows no affinity for CRF2 receptor (Ki>10 uM). |
| PC-61267 |
CP 376395 hydrochloride
CRF1 antagonist
|
A potent, selective and orally active CRF1 receptor antagonist with Ki of 12 nM, shows no affinity for CRF2 receptor (Ki>10 uM). |
| PC-21400 |
K41498
CRF2 inhibitor
|
K41498 is a potent, highly selective CRF2 receptor antagonist with Ki values of 0.66 nM, 0.62 nM and 425 nM for human CRF2α, CRF2β and CRF1 receptors respectively. |
| PC-21399 |
NBI-35965
CRF1 inhibitor
|
NBI-35965 is a potent, selective antagonist of corticotropin-releasing factor 1 (CRF1) receptor with Ki of 4 nM, >1000-fold selective over CRF2. |
| PC-21398 |
NBI-27914
CRF1 inhibitor
|
NBI-27914 is a potent, selective antagonist of corticotropin-releasing factor 1 (CRF1) receptor with Ki of 1.7 nM, shows no activity at CRF2 receptors. |
| PC-21280 |
R121919
CRF1R inhibitor
|
R121919 (NBI30775) is a highly potent, selective and nonpeptide antagonist of corticotropin-releasing factor 1 (CRF1) receptor with binding Ki of 3 nM (human and rat CRHR1), inhibits CRHR1-mediated signal transduction in transfected cells with IC50 of 60 nM. |
