Antalarmin

Chemical Structure : Antalarmin

CAS No.: 157284-96-3

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货号: PC-23838Not For Human Use, Lab Use Only.

Antalarmin is a potent, selective nonpeptide corticotropin-releasing factor receptor 1 (CRHR1, CRF1) antagonist with Ki of 2.7 nM, with no effect on CRF2 receptor.

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10 mg	￥3580	In stock
25 mg	￥5780	In stock
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生物&药学活性

Antalarmin is a potent, selective nonpeptide corticotropin-releasing factor receptor 1 (CRHR1, CRF1) antagonist with Ki of 2.7 nM, with no effect on CRF2 receptor.
Antalarmin potently displaced 125I-oCRH binding, exhibiting respectively Ki values of 1. 9 nM, 1.3 nM, and 1.4 nM in pituitary, cerebellum, and frontal cortex ho- mogenates.
Antalarmnin (20 mg/kg body wt.) significantly inhibited CRH-stimulated ACTH release and carageenin-induced subcutaneous inflammation in rats.

物理化学性质&存储条件

分子量	378.56
分子式	C24H34N4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-Butyl-N-ethyl-7-mesityl-2,5,6-trimethyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine

参考文献

1. Deak T, et al. Endocrinology. 1999 Jan;140(1):79-86.

2. Webster EL, et al. Endocrinology. 1996 Dec;137(12):5747-50.

Antalarmin

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