R121919 | CRF1R inhibitor | Probechem Biochemicals

Chemical Structure : R121919

CAS No.: 195055-03-9

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R121919 (R 121919, NBI30775)

货号: PC-21280Not For Human Use, Lab Use Only.

规格	价格	库存
25 mg	￥1780	In stock
50 mg	￥2880	In stock
100 mg	￥4580	In stock
200 mg		Get quote
1 g		Get quote

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生物&药学活性

R121919 (NBI30775) is a highly potent, selective and nonpeptide antagonist of corticotropin-releasing factor 1 (CRF1) receptor with binding Ki of 3 nM (human and rat CRHR1), inhibits CRHR1-mediated signal transduction in transfected cells with IC50 of 60 nM.
R121919 has a 1000-fold lower affinity to 70 other central receptors tested.
R121919 dose-dependently suppresses CRH-induced ACTH secretion in rat corticotrope cells.
R121919 attenuates the behavioral and endocrine responses to stress in rats.

物理化学性质&存储条件

分子量	380.54
分子式	C22H32N6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	3-[6-(dimethylamino)-4-methyl-pyrid-3-yl]-2,5-dimethyl-N,N-dipropyl-pyrazolo[2,3-a]pyrimidin-7-amine

参考文献

1. Gutman DA, et al. J Pharmacol Exp Ther. 2003 Feb;304(2):874-80.

2. Lancel M, et al. J Psychiatr Res. 2002 Jul-Aug;36(4):197-208.

3. M E Keck, et al. Eur J Neurosci. 2001 Jan;13(2):373-80.

R121919 (R 121919, NBI30775)

生物&药学活性

物理化学性质&存储条件

参考文献

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R121919 (R 121919, NBI30775)

生物&药学活性

物理化学性质&存储条件

参考文献

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