PC-21280 |
R121919
CRF1R inhibitor
|
R121919 (NBI30775) is a highly potent, selective and nonpeptide antagonist of corticotropin-releasing factor 1 (CRF1) receptor with binding Ki of 3 nM (human and rat CRHR1), inhibits CRHR1-mediated signal transduction in transfected cells with IC50 of 60 nM. |