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首页-小分子抑制剂&激动剂-GPCR-CRF Receptor-NBI-35965
NBI-35965

Chemical Structure : NBI-35965

CAS No.: 268546-19-6

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NBI-35965 (NBI 35965)

货号: PC-21399Not For Human Use, Lab Use Only.

NBI-35965 is a potent, selective antagonist of corticotropin-releasing factor 1 (CRF1) receptor with Ki of 4 nM, >1000-fold selective over CRF2.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

NBI-35965 is a potent, selective antagonist of corticotropin-releasing factor 1 (CRF1) receptor with Ki of 4 nM, >1000-fold selective over CRF2.
NBI-35965 inhibits cAMP accumulation and adrenocorticotropic hormone (ACTH) production in vitro with pIC50 values of 7.1 and 6.9 respectively.
NBI-35965 attenuates CRF and ACTH production in vivo.
NBI-35965 is orally active and brain penetrant with anxiolytic activity.

物理化学性质&存储条件

分子量 401.34
分子式 C21H22Cl2N4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(7S)-6-(Cyclopropylmethyl)-2-(2,4-dichlorophenyl)-7-ethyl-7,8-dihydro-4-methyl-6H-1,3,6,8a-tetraazaacenaphthylene

参考文献

1. Mulugeta Million, et al. Brain Res. 2003 Sep 19;985(1):32-42.

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