CRF1 Receptor Antagonist M43

Chemical Structure : CRF1 Receptor Antagonist M43

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货号: PC-25856Not For Human Use, Lab Use Only.

CRF1 Receptor Antagonist M43 is a potent, selective nonpeptide corticotropin-releasing factor receptor 1 (CRHR1, CRF1) with Ki of 19.2 nM.

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生物&药学活性

CRF1 Receptor Antagonist M43 is a potent, selective nonpeptide corticotropin-releasing factor receptor 1 (CRHR1, CRF1) with Ki of 19.2 nM.
M43 inhibits cAMP accumulation stimulated by 10 nM Tyr0-sauvagine in a dose–response manner, with an antagonistic potency of 43.5 nM (pIC50 = 7.36).
M43 inhibits the proliferation rate of RAW 264.7 macrophages stimulated by 10 nM of Tyr0-sauvagine.

物理化学性质&存储条件

分子量	460.80
分子式	C18H20Cl3N5OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(Z)-7-(butyl(ethyl)amino)-5-methyl-3-(2,4,6-trichlorophenyl)thiazolo[4,5-d]pyrimidin-2(3H)-one oxime

参考文献

1. Giatro SM, et al. Biomolecules. 2025 Sep 1;15(9):1265.