CP 376395 hydrochloride | CRF1 antagonist | Probechem Biochemicals

Chemical Structure : CP 376395 hydrochloride

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CP 376395 hydrochloride (CP376395, CP-376395)

货号: PC-61267Not For Human Use, Lab Use Only.

A potent, selective and orally active CRF1 receptor antagonist with Ki of 12 nM, shows no affinity for CRF2 receptor (Ki>10 uM).

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生物&药学活性

CP 376395 hydrochloride is a potent, selective and orally active CRF1 receptor antagonist with Ki of 12 nM, shows no affinity for CRF2 receptor (Ki>10 uM).
CP 376395 significantly attenuates activation of the HPA axis (MED=10 mg/kg, p.o), reverses the excitation of locus coeruleus neurons induced by CRF in CNS in vivo.

物理化学性质&存储条件

分子量	362.942
分子式	C21H31ClN2O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(mesityloxy)-3,6-dimethyl-N-(pentan-3-yl)pyridin-4-amine hydrochloride

参考文献

1. Chen YL, et al. J Med Chem. 2008 Mar 13;51(5):1385-92.

2. Blacktop JM, et al. J Neurosci. 2011 Aug 3;31(31):11396-403.

3. Simms JA, et al. Addict Biol. 2014 Jul;19(4):606-11.

CP 376395 hydrochloride (CP376395, CP-376395)

生物&药学活性

物理化学性质&存储条件

参考文献

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CP 376395 hydrochloride (CP376395, CP-376395)

生物&药学活性

物理化学性质&存储条件

参考文献

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