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首页-小分子抑制剂&激动剂-GPCR-CRF Receptor-SSR125543
SSR125543

Chemical Structure : SSR125543

CAS No.: 752253-39-7

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SSR125543 (Crinecerfont;SSR-125543)

货号: PC-36089Not For Human Use, Lab Use Only.

SSR125543 (Crinecerfont, SSR-125543) is a potent, nonpeptide, orally active corticotropin-releasing factor (CRF) receptor CRF1 antagonist, shows anxiolytic- and antidepressant-like activities in vivo. .

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5 mg ￥2580 In stock
10 mg ￥3980 In stock
25 mg ￥5980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

SSR125543 (Crinecerfont, SSR-125543) is a potent, nonpeptide, orally active corticotropin-releasing factor (CRF) receptor CRF1 antagonist, shows anxiolytic- and antidepressant-like activities in vivo.

物理化学性质&存储条件

分子量 483.042
分子式 C27H28ClFN2OS
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-(2-chloro-4-methoxy-5-methylphenyl)-N-[(1S)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]-5-methyl-N-(prop-2-yn-1-yl)-1,3-thiazol-2-amine

参考文献

1. Louis C, et al. Neuropsychopharmacology. 2006 Oct;31(10):2180-7.

2. Overstreet DH, et al. Eur J Pharmacol. 2004 Aug 16;497(1):49-53.

3. Claustre Y, et al. Neuroscience. 2006 Sep 1;141(3):1481-8.

4. Urani A, et al. Pharmacol Biochem Behav. 2011 May;98(3):425-31.

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