| Cat. No. |
Product Name |
Information |
| PC-42134 |
CFMTI
mGluR1 antagonist
|
CFMTI is a potent, selective, allosteric and oral mGluR1 antaognist with IC50 of 2.6 and 2.3 nM for human and rat mGluR1, respectively. |
| PC-45423 |
JNJ-42153605
mGlu2 PAM
|
JNJ-42153605 is a potent, selective positive allosteric modulator of mGlu2 receptor with EC50 of 17 nM. |
| PC-42135 |
Ro 67-7476
p-ERK1/2 agonist, rat mGlu1R PAM
|
Ro 67-7476 is a potent, selective positive allosteric modulator (potentiator) of rat mGlu1R with pEC50 of 6.76 for the potentiation of 3 uM glutamate-induced Ca2+ int currents. |
| PC-42140 |
PHCCC
mGluR4 PAM
|
PHCCC is a potent, selective allosteric potentiator of mGluR4 with EC50 of 4.1 uM, also is a selective antagonist of group mGlu1 receptors. |
| PC-45568 |
LY354740
group 2 mGluR agonist
|
LY354740 (Eglumegad) is a potent and selective group 2 mGluRs agonist with IC50 of 5 nM and 24 nM on transfected human mGlu2 and mGlu3 receptors, respectively. |
| PC-45947 |
LY341495
mGluR2/3 antagonist
|
LY341495 (LY-341495) is a potent and selective antagonist of the group II mGluRs with IC50 of 21 nM and 14 nM for mGluR2 and mGluR3, respectively. |
| PC-42118 |
(RS)-MCPG
mGluR antagonist
|
(RS)-MCPG is a non-selective group I/group II metabotropic glutamate receptor (mGluR) antagonist. |
| PC-42119 |
E4CPG
mGluR antagonist
|
E4CPG is a non-selective group I/group II metabotropic glutamate receptor (mGluR) antagonist. |
| PC-45635 |
Trans-ACPD
mGluR agonist
|
Trans-ACPD is a equimolecular mixture of (1S,3R)- and (1R,3S)-ACPD, selective agonist for metabotropic glutamate receptors. |
| PC-27667 |
VU0424465
mGlu5 ago-PAM
|
VU0424465 (ML273) is a potent, selective agonist/positive allosteric modulator (ago-PAM) of mGlu5 receptor with radioligand binding IC50 of 7.3 nM and EC50 of 9.4 nM. |
| PC-27666 |
AE90015
mGlu5 NAM
|
AE90015 is a highly specific, effective negative allosteric modulator (NAM) for the human mGlu5 receptor (mGluR5), exhibiting an impressive affinity of 18.5 nM. |
| PC-27664 |
JF-NP-26
mGlu5 NAM
|
JF-NP-26 is a selecitve, photoactive mGlu5 receptor negative allosteric modulator (NAM), elicits with light pulses in the visible spectrum (405 nm), induces light-dependent analgesia in models of inflammatory and neuropathic pain in freely behaving animals. |
