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首页-小分子抑制剂&激动剂-GPCR-mGluR-JNJ-42153605
JNJ-42153605

Chemical Structure : JNJ-42153605

CAS No.: 1254977-87-1

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JNJ-42153605 (JNJ42153605, JNJ 42153605)

货号: PC-45423Not For Human Use, Lab Use Only.

JNJ-42153605 is a potent, selective positive allosteric modulator of mGlu2 receptor with EC50 of 17 nM.

规格 价格 库存 数量
10 mg ￥1580 In stock
25 mg ￥2580 In stock
50 mg ￥4280 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

JNJ-42153605 is a potent, selective positive allosteric modulator of mGlu2 receptor with EC50 of 17 nM.
JNJ-42153605 displays >100-fold selectivity over mGlu1,3-8 receptors.
JNJ-42153605 shows a central in vivo efficacy by inhibition of REM sleep state (3 mg/kg, po) in the rat sleep–wake EEG paradigm; reverses PCP-induced hyperlocomotion ( ED50 of 5.4 mg/kg, sc).

物理化学性质&存储条件

分子量 400.44
分子式 C22H23F3N4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: 10 mM
Chemical Name/SMILES

1,2,4-Triazolo[4,3-a]pyridine, 3-(cyclopropylmethyl)-7-(4-phenyl-1-piperidinyl)-8-(trifluoromethyl)-

参考文献

1. Cid JM, et al. J Med Chem. 2012 Oct 25;55(20):8770-89.

2. Wyckhuys T, et al. J Pharmacol Exp Ther. 2014 Aug;350(2):375-86.

3. Megens AA, et al. Eur J Pharmacol. 2014 Mar 15;727:130-9.

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