PHCCC

Chemical Structure : PHCCC

CAS No.: 179068-02-1

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货号: PC-42140Not For Human Use, Lab Use Only.

PHCCC is a potent, selective allosteric potentiator of mGluR4 with EC50 of 4.1 uM, also is a selective antagonist of group mGlu1 receptors.

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25 mg	￥1580	In stock
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PHCCC is a potent, selective allosteric potentiator of mGluR4 with EC50 of 4.1 uM, also is a selective antagonist of group mGlu1 receptors.
PHCCC potentiates the response to glutamate (2 uM) 5.6-fold compared with glutamate alone in FLIPR assay.
PHCCC shows significant, dose-dependent anticonflict effects without affecting the threshold current or water intake in rats.
PHCCC also reduces proliferation and promotes differentiation of cerebellar granule cell neuroprecursors in rats.

物理化学性质&存储条件

分子量	294.3047
分子式	C17H14N2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	DMSO: ≥ 32 mg/mL
Chemical Name/SMILES	Benzo[b]cyclopropa[e]pyran-1a(1H)-carboxamide, 7,7a-dihydro-7-(hydroxyimino)-N-phenyl-

参考文献

1. Stachowicz K, et al. Eur J Pharmacol. 2004 Sep 13;498(1-3):153-6.

2. Canudas AM, et al. J Neurosci. 2004 Nov 17;24(46):10343-52.

3. Marino MJ, et al. Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13668-73.

PHCCC

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物理化学性质&存储条件

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PHCCC

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