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首页-小分子抑制剂&激动剂-GPCR-mGluR-LY354740
LY354740

Chemical Structure : LY354740

CAS No.: 176199-48-7

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LY354740 (Eglumegad, Eglumetad, LY-354740)

货号: PC-45568Not For Human Use, Lab Use Only.

LY354740 (Eglumegad) is a potent and selective group 2 mGluRs agonist with EC50s of 55 ± 17 nM.

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5 mg ￥1380 In stock
10 mg ￥2180 In stock
25 mg ￥3980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

LY354740 (Eglumegad) is a potent and selective group 2 mGluRs agonist with EC50s of 55 ± 17 nM.
LY354740 possesses no activity at iGluR or group 1 mGluR (>100 uM).
LY354740 shows anticonvulsant and anxiolytic properties in vivo; orally active.

物理化学性质&存储条件

分子量 185.1772
分子式 C8H11NO4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: < 1.9 mg/mL
Chemical Name/SMILES

Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1S,2S,5R,6S)-

参考文献

1. Monn JA, et al. J Med Chem. 1997 Feb 14;40(4):528-37.

2. Menezes MM, et al. Neurosci J. 2013;2013:736439.

3. Profaci CP, et al. Psychopharmacology (Berl). 2011 Jul;216(2):235-43.

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