Ro 67-7476 | p-ERK1/2 agonist, rat mGlu1R PAM | Probechem Biochemicals

Chemical Structure : Ro 67-7476

CAS No.: 298690-60-5

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Ro 67-7476 (Ro67-7476, Ro-67-7476)

货号: PC-42135Not For Human Use, Lab Use Only.

Ro 67-7476 is a potent, selective positive allosteric modulator (potentiator) of rat mGlu1R with pEC50 of 6.76 for the potentiation of 3 uM glutamate-induced Ca2+ int currents.

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10 mg	￥1380	In stock
25 mg	￥2480	In stock
50 mg	￥3980	In stock
100 mg		Get quote

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生物&药学活性

Ro 67-7476 is a potent, selective positive allosteric modulator (potentiator) of rat mGlu1R with pEC50 of 6.76 for the potentiation of 3 uM glutamate-induced Ca2+ int currents.
Ro 67-7476 also is a potent p-ERK1/2 agonist and activates ERK1/2 phosphorylation in the absence of exogenously added glutamate
Ro 67-7476 has no activity for mGluR5 at 1 uM and Adrenergic α1, α2, β1, β2 and GABAA at 10 uM.
Ro 67-7476 has no effect on the glutamate-induced currents in human mGlu1a receptor-expressing cells.

物理化学性质&存储条件

分子量	319.3937
分子式	C17H18FNO2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	DMSO: ≥ 40 mg/mL
Chemical Name/SMILES	Pyrrolidine, 2-(4-fluorophenyl)-1-[(4-methylphenyl)sulfonyl]-, (2S)-

参考文献

1. Hemstapat K, et al. Mol Pharmacol. 2006 Aug;70(2):616-26.

2. Knoflach F, et al. Proc Natl Acad Sci U S A. 2001 Nov 6;98(23):13402-7.

3. Sheffler DJ, et al. Neuropharmacology. 2008 Sep;55(4):419-27.

Ro 67-7476 (Ro67-7476, Ro-67-7476)

生物&药学活性

物理化学性质&存储条件

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Ro 67-7476 (Ro67-7476, Ro-67-7476)

生物&药学活性

物理化学性质&存储条件

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