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首页-小分子抑制剂&激动剂-GPCR-mGluR-VU0364770
VU0364770

Chemical Structure : VU0364770

CAS No.: 61350-00-3

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VU0364770 (VU-0364770, VU 0364770)

货号: PC-42205Not For Human Use, Lab Use Only.

VU0364770 is a potent, selective, systemically active positive allosteric modulator of mGlu4R with EC50 of 1.1 uM.

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25 mg ￥1280 In stock
50 mg ￥1980 In stock
100 mg ￥2980 In stock
250 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

VU0364770 is a potent, selective, systemically active positive allosteric modulator of mGlu4R with EC50 of 1.1 uM.
VU0364770 does not significantly bind to a panel of 68 GPCRs, ion channels and transporters.
VU0364770 produces efficacy alone and in combination with L-DOPA or an adenosine 2A antagonist in preclinical rodent models of Parkinson's disease.

物理化学性质&存储条件

分子量 232.6657
分子式 C12H9ClN2O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-Pyridinecarboxamide, N-(3-chlorophenyl)-

参考文献

1. Jones CK, et al. J Pharmacol Exp Ther. 2012 Feb;340(2):404-21.

2. Iderberg H, et al. Neuropharmacology. 2015 Aug;95:121-9.

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