LY341495 | mGluR2/3 antagonist | Probechem Biochemicals

Chemical Structure : LY341495

CAS No.: 201943-63-7

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LY341495 (LY 341495, LY-341495)

货号: PC-45947Not For Human Use, Lab Use Only.

LY341495 (LY-341495) is a potent and selective antagonist of the group II mGluRs with IC50 of 21 nM and 14 nM for mGluR2 and mGluR3, respectively.

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5 mg	￥880	In stock
10 mg	￥1280	In stock
25 mg	￥2180	In stock
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100 mg		Get quote

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生物&药学活性

LY341495 (LY-341495) is a potent and selective antagonist of the group II mGluRs with IC50 of 21 nM and 14 nM for mGluR2 and mGluR3, respectively.
LY341495 shows less effectively blocks mGluR8 and mGluR7 (IC50=173 and 990 nM) and weakly antagonizes mGluR1, mGluR5, and mGluR4 (IC50s = 6.8, 8.2, and 22 uM).
LY341495 penetrates the blood-brain barrier and has been used to study the roles of mGlu2/3 receptors in the brain.

物理化学性质&存储条件

分子量	353.3686
分子式	C20H19NO5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	9H-Xanthene-9-propanoic acid, .alpha.-amino-.alpha.-[(1S,2S)-2-carboxycyclopropyl]-, (.alpha.S)-

参考文献

1. Collado I, et al. Bioorg Med Chem Lett. 1998 Oct 20;8(20):2849-54.

2. Schaffhauser H, et al. Mol Pharmacol. 1998 Feb;53(2):228-33.

3. Chung DS, et al. J Pharmacol Exp Ther. 1997 Nov;283(2):742-9.

LY341495 (LY 341495, LY-341495)

生物&药学活性

物理化学性质&存储条件

参考文献

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LY341495 (LY 341495, LY-341495)

生物&药学活性

物理化学性质&存储条件

参考文献

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