| Cat. No. |
Product Name |
Information |
| PC-21503 |
SYHA1813
CSF1R/VEGFR inhibitor
|
SYHA1813 is a potent dual inhibitor of CSF1R and VEGFR with IC50 of 19.3, 2.8, 0.3, and 4.3 nM for CSF1R, VEGFR1, 2, and 3, respectively. |
| PC-20795 |
Chiauranib
Multikinase inhibitor
|
Chiauranib (Ibcasertib, CS2164) is a potent multi-kinase inhibitor, inhibits VEGFR2, Aurora B and CSF‐1R kinases with IC50 values of 7, 9 and 7 nM, respectively. |
| PC-20338 |
EVT801
VEGFR-3 inhibitor
|
EVT801 (EVT 801) is a potent, selective VEGFR-3 inhibitor with biochemical IC50 of 11 nM, inhibits cellular VEGFR-3 autophosphorylation with IC50 of 39 nM. |
| PC-38754 |
VEGFR inhibitor F16
Angiogenesis inhibitor
|
F16 is a novel specific angiogenesis inhibitor, effectively reduces cell proliferation, tube formation, and migration of HUVECs in a concentration-dependent manner by directly inhibiting VEGF binding and subsequent VEGFR-2 phosphorylation. |
| PC-38423 |
Timtraxanib
VEGFR-2 inhibitor
|
Timtraxanib (AVI 3207) is a peptide mimetic acting as a selective VEGFR-2 inhibitor, inhibits VEGF-2 selectively for curing senile macular degeneration. |
| PC-35892 |
AL3810
VEGFR inhibitor
|
AL3810 (AL-3810, E-3810, Lucitanib) is a potent, orally bioavailable, multiple tyrosine kinases inhibitor, potently inhibits VEGFR1/2/3 (IC50=7-25 nM) and FGFR1/2/3 (IC50=17.5-235 nM), also inhibits CSF1R with IC50 of 5 nM. |
| PC-35130 |
EG00229 free base
VEGF-A/NRP1 inhibitor
|
EG00229 is a specific inhibitor of neuropilin-1 (NRP1)/VEGF-A interaction, inhibits the binding of biotinylated VEGFA to NRP1 with IC50 of 8 uM. |
| PC-35129 |
EG01377
NRP1 inhibitor
|
EG01377 is a potent and bioavailable inhibitor of the NRP1/VEGF-A interaction (Kd=1.32 uM), selective for NRP1 over the closely related protein NRP2. |
| PC-63554 |
TAS-115
VEGFR2/c-Met inhibitor
|
TAS-115 (Pamufetinib) is a potent, dual VEGFR2/c-Met inhibitor with IC50 of 30 and 32 nM against rVEGFR2 and rMET, respectively. |
| PC-43506 |
Apatinib
Multikinase inhibitor
|
Apatinib (YN968D1) is a multitargeted tyrosine kinase inhibitor (TKI) that inhibits VEGFR-2 (Flk-1/KDR, IC50=1 nM), RET, c-Kit and c-Src (IC50=13, 429 and 530 nM respectively). |
| PC-43483 |
Regorafenib hydrochloride
VEGFR inhibitor
|
Regorafenib hydrochloride (BAY73-4506) is a potent, orally active multikinase inhibitor that potently inhibits endothelial cell kinases in biochemical and cellular kinase phosphorylation assays with nanomolar range (IC50=3-200 nM). |
| PC-63493 |
CEP-7055
VEGFR inhibitor
|
CEP-7055 is a potent, orally active, pan inhibitor of VEGFR, CEP-7055 is the dimethylglycine ester prodrug of CEP-5214, which inhibits human VEGFR2/KDR kinase, VEGFR1/FLT-1 kinase, and VEGFR3/FLT-4 kinase with IC50 of 18 nM, 12 nM, and 17 nM. |
