NRPa-308 | NRP1 inhibitor | Probechem Biochemicals

Chemical Structure : NRPa-308

加入收藏

NRPa-308 (NRPa 308)

货号: PC-21447Not For Human Use, Lab Use Only.

NRPa-308 is a neuropilin-1 (NRP-1) antagonist, inhibits the VEGF-A165/NRP-1 binding with IC50 of 42 uM, exerts in vitro anti-angiogenic activity.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
200 mg		Get quote
1 g		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

NRPa-308 is a small molecule neuropilin-1 (NRP-1) antagonist, inhibits the VEGF-A165/NRP-1 binding with IC50 of 42 uM, exerts in vitro anti-angiogenic activity.
NRPa-308 exhibits cellular activity with IC50 of 0.5 uM on a human aggressive and metastatic estrogenR−/progesteroneR−/Her2- breast cancer cell line (MDA-MB-231).
NRPa-308 dramatically inhibits tubulogenesis for HUVEC tubule formation in a collagen gel under VEGF-A165 stimulation.
NRPa-308 (50 mg/kg) improves the median survival and reduces the tumour growth on mice xenografted with human breast cancer cells (MDA-MB-231), does not exert visible acute toxicity.

物理化学性质&存储条件

分子量	424.52
分子式	C23H24N2O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2-ethoxyphenyl)-4-methyl-3-(N-(p-tolyl)sulfamoyl)benzamide

参考文献

1. Wang-Qing Liu, et al. Cancer Lett. 2018 Feb 1:414:88-98.

NRPa-308 (NRPa 308)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

NRPa-308 (NRPa 308)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.