TU2218 | ALK5/VEGFR2 inhibitor | Probechem Biochemicals

Chemical Structure : TU2218

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TU2218 (TU-2218)

货号: PC-22874Not For Human Use, Lab Use Only.

TU2218 is a small-molecule inhibitor that inhibits dual ALK5/VEGFR2 with IC50 of 1.2 nM and 4.5 nM respectively.

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100 mg		Get quote

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生物&药学活性

TU2218 is a small-molecule inhibitor that inhibits dual ALK5/VEGFR2 with IC50 of 1.2 nM and 4.5 nM respectively.
TU2218 shows an IC50 of 101 nM in the SMAD2 phosphorylation assay using human whole blood and an IC50 of 52.5 nM in the VEGFR2 phosphorylation assay in human umbilical vein endothelial cells (HUVECs).
TU2218 inhibits immunosuppression induced by TGFβ or coculture with cancer cells or deficient costimulatory signal.
TU2218 blocks suppressive activity of regulatory T cell for proliferation of TCR-elicited effector T lymphocytes.
TU2218 normalizes the endothelial cell inactivation through inhibiting VEGF-VEGFR2 axis.
TU2218 induces antitumor activity in combination with anti-PD1 in B16F10 syngeneic model.

物理化学性质&存储条件

分子量	317.36
分子式	C17H15N7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-(6-(6-methylpyridin-2-yl)-2,3-dihydro-1H-imidazo[1,2-a]imidazol-5-yl)-[1,2,4]triazolo[1,5-a]pyridine

参考文献

1. Kim NH, et al. Cancer Immunol Immunother. 2024 Aug 6;73(10):190.

TU2218 (TU-2218)

生物&药学活性

物理化学性质&存储条件

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TU2218 (TU-2218)

生物&药学活性

物理化学性质&存储条件

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