EG01377 dihydrochloride

Chemical Structure : EG01377 dihydrochloride

CAS No.: 2749438-61-5

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货号: PC-23664Not For Human Use, Lab Use Only.

EG01377 dihydrochloride is a potent and bioavailable inhibitor of the NRP1/VEGF-A interaction (Kd=1.32 uM), selective for NRP1 over the closely related protein NRP2.

规格	价格	库存
5 mg	￥2980	In stock
10 mg	￥4580	In stock
25 mg	￥7580	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

EG01377 dihydrochloride is a potent and bioavailable inhibitor of the NRP1/VEGF-A interaction (Kd=1.32 uM), selective for NRP1 over the closely related protein NRP2.
EG01377 demonstrates antiangiogenic, antimigratory, and antitumor effects in in vitro assays.
EG01377 blocks glioma-conditioned medium-induced increase in TGFβ production in purified Nrp1+, FoxP3+, and CD25+ populations of Tregs from mice.

物理化学性质&存储条件

分子量	659.60
分子式	C26H32Cl2N6O6S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3-((5-(4-(Aminomethyl)phenyl)-2,3-dihydrobenzofuran)-7-sulfonamido)thiophene-2-carbonyl)-L-arginine dihydrochloride

参考文献

1. Powell J, et al. J Med Chem. 2018 May 10;61(9):4135-4154.

2. Jarvis A, et al. J Med Chem. 2010 Mar 11;53(5):2215-26.