Amentoflavone

Chemical Structure : Amentoflavone

CAS No.: 1617-53-4

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货号: PC-25873Not For Human Use, Lab Use Only.

规格	价格	库存
5 mg	￥580	In stock
10 mg	￥880	In stock
25 mg	￥1380	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

Amentoflavone is a naturally occurring biflavonoid with anti-inflammatory and anti-tumor properties, an antiangiogenic bioactive molecule that binds VEGFs preventing the interaction and phosphorylation of VEGF receptor 1 and 2 (VEGFR-1,VEGFR-2).
Amentoflavone significantly inhibited GLI-1-mediated CRC cell proliferation, induced G1 phase arrest, and downregulated Cyclin D1/CDK4 expression, by targeting the GLI-1/IL-6/STAT3 signaling axis.
Amentoflavone inhibited endothelial cell migration and capillary-like tube formation induced by VEGF-A or placental growth factor 1 (PlGF-1) at low uM concentration.
Amentoflavone inhibited VEGF-A-induced chorioallantoic membrane neovascularization as well as tumor growth and associated neovascularization, as assessed in orthotropic melanoma and xenograft colon carcinoma models.

物理化学性质&存储条件

分子量	538.46
分子式	C30H18O10
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	8-(5-(5,7-Dihydroxy-4-oxo-4H-chromen-2-yl)-2-hydroxyphenyl)-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one

参考文献

1. Gele T, et al. J Cell Mol Med. 2025 Oct;29(20):e70825.

2. Chen R, et al. Int Immunopharmacol. 2025 Nov 14;165:115450.

3. Fang YJ, et al. Biomed Pharmacother. 2025 Oct;191:118435.

4. Tarallo V, et al. J Biol Chem. 2011 Jun 3;286(22):19641-51.

Amentoflavone

生物&药学活性

物理化学性质&存储条件

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Amentoflavone

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