VEGFR inhibitor F16

Chemical Structure : VEGFR inhibitor F16

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货号: PC-38754Not For Human Use, Lab Use Only.

F16 is a novel specific angiogenesis inhibitor, effectively reduces cell proliferation, tube formation, and migration of HUVECs in a concentration-dependent manner by directly inhibiting VEGF binding and subsequent VEGFR-2 phosphorylation.

规格	价格	库存	数量
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250 mg		Get quote

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生物&药学活性

F16 is a novel specific angiogenesis inhibitor, effectively reduces cell proliferation, tube formation, and migration of HUVECs in a concentration-dependent manner by directly inhibiting VEGF binding and subsequent VEGFR-2 phosphorylation.
F16 is also able to inhibit the PI3K/PKB-mediated survival and migration pathways in cancer in addition to inhibiting the FAK and MAPKs-mediated signaling in GI-101A cancer cells.
F16 is a specific inhibitor of angiogenesis in both in vitro and in vivo models.
F16 also works very efficiently with Taxol in combination by limiting the tumor growth that is better than the monotherapy with any one of the drugs that were tested individually.

物理化学性质&存储条件

分子量	301.214
分子式	C13H7N3O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2,3-Dihydro-1,3-dioxo-1H-isoindol-4-yl)-5-nitro-2-furancarboxamide

参考文献

1. Appu Rathinavelu, et al. Tumour Biol. 2017 Nov;39(11):1010428317726841.