| Cat. No. |
Product Name |
Information |
| PC-27536 |
Etoposide
Topo II inhibitor, CD44 inhibitor
|
Etoposide (VP-16-213) is a topoisomerase II inhibitor that disrupts DNA replication and transcription, induces cell cycle arrest, apoptosis and autophagy, also inhibits Hyaluronic acid (HA)-CD44 interaction. |
| PC-25511 |
Banoxantrone dihydrochloride
Topo II inhibitor
|
Banoxantrone dihydrochloride (AQ4N) is an alkylaminoanthraquinone-di-N-oxide anticancer prodrug, potentiates the anti-tumour effect of cisplatin, AQ4N is metabolised in hypoxic cells by cytochrome P450s (CYPs) to the cytotoxin AQ4, which is a stable, DNA-affinic compound and potent topoisomerase II inhibitor. |
| PC-25441 |
(S)-10-Hydroxycamptothecin
Topo I inhibitor, DHHC9 inhibitor
|
(S)-10-Hydroxycamptothecin (10-HCPT, 10-Hydroxycamptothecin) is a DNA topoisomerase I inhibitor with remarkable apoptosis-inducing effect, also is a potent DHHC9 inhibitor that effectively suppressed adenocarcinoma cell migration. |
| PC-25320 |
TAS-103 dihydrochloride
Topoisomerase inhibitor
|
TAS-103 dihydrochloride (BMS-247615) is an effective small molecule inhibitor of topoisomerases I and II (Topo I and Topo II) with IC50 of 2 uM and 6.5 uM, shows cytotoxic effect on P388 and KB cells with IC50 of 1.1 nM and 9.6 nM respectively. |
| PC-25319 |
TAS-103
Topoisomerase inhibitor
|
TAS-103 (BMS-247615) is an effective small molecule inhibitor of topoisomerases I and II (Topo I and Topo II) with IC50 of 2 uM and 6.5 uM, shows cytotoxic effect on P388 and KB cells with IC50 of 1.1 nM and 9.6 nM respectively. |
| PC-24967 |
Annamycin
Topo II inhibitor
|
Annamycin (Naxtarubicin) is a highly lipophilic anthracycline antibiotic that has been shown to circumvent MDR-1 both in vitro and in vivo, intercalates into DNA and inhibits topoisomerase II, thereby inhibiting DNA replication and repair as well as inhibiting RNA and protein synthesis. |
| PC-24928 |
Merbarone
Topo II inhibitor
|
Merbarone (NSC 336628) is a potent, orally active DNA topoisomerase II (Topo II) inhibitor, inhibits topoisomerase II-mediated DNA cleavage without stabilizing topo II-DNA covalent complexes. |
| PC-24552 |
(R)-WAC-224
Topo II inhibitor
|
(R)-WAC-224 is an anticancer quinolone taht demonstrates cell growth inhibition against venetoclax-resistant AML cells (MOLM-13, IC50=0.02 uM), directly inhibits topoisomerase-2 (Topo-II) and exhibits antileukemic effects both in vitro and in vivo. |
| PC-24351 |
ICRF-193
Topo II inhibitor
|
ICRF-193 is a catalytic inhibitor of DNA topoisomerase II (TOP2). |
| PC-23976 |
Irinotecan
Topo I inhibitor
|
Irinotecan ((+)-Irinotecan) is a topoisomerase I inhibitor, preventing religation of the DNA strand by binding to topoisomerase I-DNA complex. |
| PC-22736 |
Pixantrone
Topo II inhibitor, MCM2 inhibitor
|
Pixantrone (BBR2778) dimaleate is a topoisomerase II inhibitor and DNA intercalator with anti-tumor activity, also is a direct mini-chromosome maintenance protein 2 (MCM2) inhibitor, induces cell cycle arrest and apoptosis in ovarian cancer cells via targeting MCM2. |
| PC-22289 |
Epirubicin hydrochloride
Foxp3 inhibitor, Topo inhibitor
|
Epirubicin hydrochloride (4'-Epidoxorubicin hydrochloride) is a semisynthetic L-arabino derivative of doxorubicin with antineoplastic agent by inhibiting topoisomerase, also is a forkhead box protein 3 (FOXP3) inhibitor. |
