Voreloxin | Topo II inhibitor | Probechem Biochemicals

Chemical Structure : Voreloxin

CAS No.: 175414-77-4

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Voreloxin (SNS-595, Vosaroxin, AG 7352)

货号: PC-42643Not For Human Use, Lab Use Only.

Voreloxin (SNS-595;Vosaroxin;AG 7352) is a first-in-class anticancer quinolone derivative that intercalates DNA and inhibits Topoisomerase II, exhibits proliferation inhibition of AML cell lines MV4-11 and HL-60 with IC50 of 95 nM and 884 nM, respectively.

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5 mg	￥1180	In stock
10 mg	￥1880	In stock
25 mg	￥2980	In stock
50 mg	￥4980	In stock
100 mg		Get quote

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生物&药学活性

Voreloxin (SNS-595; Vosaroxin; AG 7352) is a first-in-class anticancer quinolone derivative that intercalates DNA and inhibits Topoisomerase II, exhibits proliferation inhibition of AML cell lines MV4-11 and HL-60 with IC50 of 95 nM and 884 nM, respectively.

物理化学性质&存储条件

分子量	401.4396
分子式	C18H19N5O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1,8-Naphthyridine-3-carboxylic acid, 1,4-dihydro-7-[(3S,4S)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-

参考文献

1. Scatena CD, et al. Cancer Chemother Pharmacol. 2010 Oct;66(5):881-8.

2. Hoch U, et al. Cancer Chemother Pharmacol. 2009 Jun;64(1):53-65.

3. Walsby EJ, et al. Haematologica. 2011 Mar;96(3):393-9.

Voreloxin (SNS-595, Vosaroxin, AG 7352)

生物&药学活性

物理化学性质&存储条件

参考文献

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Voreloxin (SNS-595, Vosaroxin, AG 7352)

生物&药学活性

物理化学性质&存储条件

参考文献

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