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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Topoisomerase-Etoposide
Etoposide

Chemical Structure : Etoposide

CAS No.: 33419-42-0

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Etoposide (VP-16, VP-16-213)

货号: PC-27536Not For Human Use, Lab Use Only.

Etoposide (VP-16-213) is a topoisomerase II inhibitor that disrupts DNA replication and transcription, induces cell cycle arrest, apoptosis and autophagy, also inhibits Hyaluronic acid (HA)-CD44 interaction.

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250 mg ￥580 In stock
500 mg ￥880 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Etoposide (VP-16-213) is a topoisomerase II inhibitor that disrupts DNA replication and transcription, induces cell cycle arrest, apoptosis and autophagy, also inhibits Hyaluronic acid (HA)-CD44 interaction.

物理化学性质&存储条件

分子量 588.56
分子式 C29H32O13
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(5R,5aR,8aR,9S)-9-(((4aR,6R,7R,8R,8aS)-7,8-Dihydroxy-2-methylhexahydropyrano[3,2-d][1,3]dioxin-6-yl)oxy)-5-(4-hydroxy-3,5-dimethoxyphenyl)-5,5a,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(8H)-one

参考文献

1. Fuchs, J., et al. Cancer. 1998. 83(11): p. 2400-7.

2. Chayah M, et al. Bioorg Chem. 2025 Mar;156:108212.

3. Hande KR, et al. Oncologist. 1996;1(4):234-239.

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