Chrysosplenetin

Chemical Structure : Chrysosplenetin

CAS No.: 603-56-5

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货号: PC-27641Not For Human Use, Lab Use Only.

规格	价格	库存
5 mg	￥1380	In stock
10 mg	￥2180	In stock
25 mg	￥3780	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

Chrysosplenetin is an o-methylated flavonols isolated from the leaves of Laggera pterodonta with anti-cancer effect, shows strong activity in vitro against EV71 with IC50 of 0.2 uM, also shows neuraminidase inhibitory activity, inhibits topoisomerase I and II.
Chrysosplenetin inhibits proliferation MCF-7 with an IC50 value of 0.29 uM.
Chrysosplenetin inhibits artemisinin efflux in P-gp-over-expressing Caco-2 cells and reverses P-gp/MDR1 mRNA up-regulated expression induced by artemisinin in mouse small intestine.
Chrysosplenetin promotes osteoblastogenesis of bone marrow stromal cells via Wnt/beta-catenin pathway and enhances osteogenesis in estrogen deficiency-induced bone loss.
Chrysosplenetin induces TMED3 aggregation and triggers unfolded protein response (UPR) in pancreatic cancer, shows anti-pancreatic cancer (PC) activity.

物理化学性质&存储条件

分子量	374.35
分子式	C19H18O8
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-Hydroxy-2-(4-hydroxy-3-methoxyphenyl)-3,6,7-trimethoxy-4H-chromen-4-one

参考文献

1. Şöhretoğlu D, et al. Int J Biol Macromol. 2020 Nov 15;163:1053-1059.

2. Zhang Z, et al. EMBO Mol Med. 2026 Aug 13. doi: 10.1038/s44321-026-00506-5.

3. Xu J, et al. Sci Rep. 2025 Apr 21;15(1):13701.

4. Zhu QC, et al. Eur J Pharm Sci. 2011 Oct 9;44(3):392-8.