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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Topoisomerase-Berubicin hydrochloride
Berubicin hydrochloride

Chemical Structure : Berubicin hydrochloride

CAS No.: 293736-67-1

Berubicin hydrochloride

货号: PC-28247Not For Human Use, Lab Use Only.

Berubicin hydrochloride (WP744, RTA744) is a doxorubicin analog that can penetrate and cross the blood-brain barrier, preserving DNA binding and acting as a potent topoisomerase II poison.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

Berubicin hydrochloride (WP744, RTA744) is a doxorubicin analog that can penetrate and cross the blood-brain barrier, preserving DNA binding and acting as a potent topoisomerase II poison.

物理化学性质&存储条件

分子量 670.11
分子式 C34H36ClNO11
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(8S,10S)-10-(((2R,4S,5S,6S)-4-Amino-5-(benzyloxy)-6-methyltetrahydro-2H-pyran-2-yl)oxy)-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione hydrochloride

参考文献

1. Mikaelian G, et al. J Phys Chem B. 2024 Jul 4;128(26):6291-6307.

2. Conrad CA, et al. Neurooncol Adv. 2026 Jul 31;8(1):vdag150.

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