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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Topoisomerase-Doxorubicin
Doxorubicin

Chemical Structure : Doxorubicin

CAS No.: 23214-92-8

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Doxorubicin (Hydroxydaunorubicin)

货号: PC-28248Not For Human Use, Lab Use Only.

Doxorubicin (Hydroxydaunorubicin) is a cytotoxic anthracycline antibiotic with anti-cancer chemotherapy activity, is a potent human DNA topoisomerase I and topoisomerase II inhibitor with IC50 of 0.8 μM and 2.67 μM, respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Doxorubicin (Hydroxydaunorubicin) is a cytotoxic anthracycline antibiotic with anti-cancer chemotherapy activity, is a potent human DNA topoisomerase I and topoisomerase II inhibitor with IC50 of 0.8 μM and 2.67 μM, respectively.

物理化学性质&存储条件

分子量 543.53
分子式 C27H29NO11
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(8S,10S)-10-(((2R,4S,5S,6S)-4-Amino-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione

参考文献

1. John L. Nitiss, et al. Nat Rev Cancer. 2009 May;9(5):338-50.

2. Hee-KyungRhee,et al. Bioorg Med Chem. 2007 Feb 15;15(4):1651-8.

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