| Cat. No. |
Product Name |
Information |
| PC-61874 |
XR-5000
Topoisomerase inhibitor
|
XR-5000 (Acridine Carboxamide;DACA;NSC 601316;SN-22995) is an inhibitor of topoisomerase I and II for treatment of various types of cancers. |
| PC-61465 |
C-1311 dihydrochloride
Topo II inhibitor
|
C-1311 dihydrochloride (Imidacrine, Imidazoacridone) is an imidazoacridinone analogue with potent in vivo antitumour activity, inhibits the catalytic activity of Topoisomerase II. |
| PC-60558 |
GPX-150
Topo II inhibitor
|
GPX-150 (DIDOX, 5-imino-13-deoxy-doxorubicin) is a doxorubicin analog that demonstrates anti-cancer activity without cardiotoxicity, does not inhibit topoisomerase IIβ activity at 100 uM. |
| PC-45667 |
SW-044248
Topo I inhibitor
|
SW-044248 is a potent, selective inhibitor of Topoisomerase I (Topo I), inhibits Top I differently from camptothecin, shows selective toxicity for some NSCLC cell lines. |
| PC-45203 |
Idarubicin hydrochloride
Topo II inhibitor
|
Idarubicin hydrochloride (4-Demethoxydaunorubicin) is an anthracycline antileukemic that inserts into DNA and prevents DNA unwinding by interfering with the enzyme Topoisomerase II in cancer cells. |
| PC-42763 |
Amonafide
Topo II inhibitor
|
Amonafide (AS1413) is a small molecule topoisomerase II (Topo II) inhibitor and DNA intercalator that induces apoptotic signaling by blocking the binding of Topo II to DNA. |
| PC-42639 |
Betulinic acid
Topo II inhibitor
|
Betulinic acid (Betulic acid) is a naturally occurring pentacyclic triterpenoid which has antiretroviral, antimalarial, and anti-inflammatory properties. |
| PC-42643 |
Voreloxin
Topo II inhibitor
|
Voreloxin (SNS-595;Vosaroxin;AG 7352) is a first-in-class anticancer quinolone derivative that intercalates DNA and inhibits Topoisomerase II, exhibits proliferation inhibition of AML cell lines MV4-11 and HL-60 with IC50 of 95 nM and 884 nM, respectively. |
| PC-22736 |
Pixantrone
Topo II inhibitor, MCM2 inhibitor
|
Pixantrone (BBR2778) dimaleate is a topoisomerase II inhibitor and DNA intercalator with anti-tumor activity, also is a direct mini-chromosome maintenance protein 2 (MCM2) inhibitor, induces cell cycle arrest and apoptosis in ovarian cancer cells via targeting MCM2. |
| PC-22289 |
Epirubicin hydrochloride
Foxp3 inhibitor, Topo inhibitor
|
Epirubicin hydrochloride (4'-Epidoxorubicin hydrochloride) is a semisynthetic L-arabino derivative of doxorubicin with antineoplastic agent by inhibiting topoisomerase, also is a forkhead box protein 3 (FOXP3) inhibitor. |
| PC-22288 |
Genz-644282
Topo I inhibitor
|
Genz-644282 is a potent, non-camptothecin topoisomerase I (Top1) inhibitor, shows potent activities against a panel of human tumor cell lines with IC50 of 1.8 nM-1.8 uM. |
