Idarubicin hydrochloride |CAS:57852-57-0 Probechem Biochemicals

Chemical Structure : Idarubicin hydrochloride

CAS No.: 57852-57-0

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Idarubicin hydrochloride (Idamycin, 4-Demethoxydaunorubicin hydrochloride)

货号: PC-45203Not For Human Use, Lab Use Only.

Idarubicin hydrochloride (4-Demethoxydaunorubicin) is an anthracycline antileukemic that inserts into DNA and prevents DNA unwinding by interfering with the enzyme Topoisomerase II in cancer cells.

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10 mg	￥780	In stock
25 mg	￥1180	In stock
50 mg	￥1880	In stock
100 mg		Get quote

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生物&药学活性

Idarubicin hydrochloride (4-Demethoxydaunorubicin) is an anthracycline antileukemic that inserts into DNA and prevents DNA unwinding by interfering with the enzyme Topoisomerase II in cancer cells.
Idarubicin inhibits the proliferation of MCF-7 cells with IC50 of 0.1 uM.
Idarubicin also induces histone eviction from chromatin.

物理化学性质&存储条件

分子量	533.9548
分子式	C26H28ClNO9
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5,12-Naphthacenedione, 9-acetyl-7-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,9,11-trihydroxy-, hydrochloride (1:1), (7S,9S)-

参考文献

1. Gewirtz DA, et al. Cancer Chemother Pharmacol. 1998;41(5):361-9.

2. Pang B, et al. Nat Commun. 2013;4:1908.

3. Nitiss JL. Nat Rev Cancer. 2009 May;9(5):338-50.

Idarubicin hydrochloride (Idamycin, 4-Demethoxydaunorubicin hydrochloride)

生物&药学活性

物理化学性质&存储条件

参考文献

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Idarubicin hydrochloride (Idamycin, 4-Demethoxydaunorubicin hydrochloride)

生物&药学活性

物理化学性质&存储条件

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