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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Topoisomerase-Amonafide
Amonafide

Chemical Structure : Amonafide

CAS No.: 69408-81-7

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Amonafide (AS1413, AS-1413)

货号: PC-42763Not For Human Use, Lab Use Only.

Amonafide (AS1413) is a small molecule topoisomerase II (Topo II) inhibitor and DNA intercalator that induces apoptotic signaling by blocking the binding of Topo II to DNA.

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10 mg ￥780 In stock
25 mg ￥1380 In stock
50 mg ￥2280 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Amonafide (AS1413) is a small molecule topoisomerase II (Topo II) inhibitor and DNA intercalator that induces apoptotic signaling by blocking the binding of Topo II to DNA.

物理化学性质&存储条件

分子量 283.3251
分子式 C16H17N3O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1H-Benz[de]isoquinoline-1,3(2H)-dione, 5-amino-2-[2-(dimethylamino)ethyl]-

参考文献

1. Allen SL, et al. Expert Opin Investig Drugs. 2011 Jul;20(7):995-1003.

2. Zhu H, et al. Mol Cancer Ther. 2007 Feb;6(2):484-95.

3. Liang X, et al. Mol Cancer Res. 2010 Dec;8(12):1619-32.

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