C-1311 dihydrochloride |CAS:138154-55-9 Probechem Biochemicals

Chemical Structure : C-1311 dihydrochloride

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C-1311 dihydrochloride (XLS-002;Symadex;Imidacrine;Imidazoacridone)

货号: PC-61465Not For Human Use, Lab Use Only.

C-1311 dihydrochloride (Imidacrine, Imidazoacridone) is an imidazoacridinone analogue with potent in vivo antitumour activity, inhibits the catalytic activity of Topoisomerase II.

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生物&药学活性

C-1311 dihydrochloride (Imidacrine, Imidazoacridone) is an imidazoacridinone analogue with potent in vivo antitumour activity, inhibits the catalytic activity of Topoisomerase II.
C-1311 induces p53-dependent senescence or p53-independent apoptosis and sensitizes cancer cells to radiation, also induces autophagy in a non-p53-dependent manner.
C-1311 effectively improves the radiosensitivity of a panel of cancer cell lines.

物理化学性质&存储条件

分子量	441.35
分子式	C20H26Cl2N4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-((2-(diethylamino)ethyl)amino)-8-hydroxy-6H-imidazo[4,5,1-de]acridin-6-one dihydrochloride

参考文献

1. Lamb J, et al. Br J Cancer. 1996 Nov;74(9):1359-68.

2. Skladanowski A, et al. Mol Pharmacol. 1996 May;49(5):772-80.

3. Skwarska A, et la. Oncotarget. 2017 May 9;8(19):31187-31198.

C-1311 dihydrochloride (XLS-002;Symadex;Imidacrine;Imidazoacridone)

生物&药学活性

物理化学性质&存储条件

参考文献

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C-1311 dihydrochloride (XLS-002;Symadex;Imidacrine;Imidazoacridone)

生物&药学活性

物理化学性质&存储条件

参考文献

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