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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Topoisomerase-Idarubicin
Idarubicin

Chemical Structure : Idarubicin

CAS No.: 58957-92-9

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Idarubicin ( 4-Demethoxydaunorubicin;IMI-30;NSC 256439)

货号: PC-63054Not For Human Use, Lab Use Only.

Idarubicin (4-Demethoxydaunorubicin) is an anthracycline antileukemic that inserts into DNA and prevents DNA unwinding by interfering with the enzyme Topoisomerase II in cancer cells.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Idarubicin (4-Demethoxydaunorubicin) is an anthracycline antileukemic that inserts into DNA and prevents DNA unwinding by interfering with the enzyme Topoisomerase II in cancer cells.
Idarubicin inhibits the proliferation of MCF-7 cells with IC50 of 0.1 uM.
Idarubicin also induces histone eviction from chromatin.

物理化学性质&存储条件

分子量 497.494
分子式 C26H27NO9
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(7S,9S)-9-acetyl-7-[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-8,10-dihydro-7H-tetracene-5,12-dione

参考文献

1. Gewirtz DA, et al. Cancer Chemother Pharmacol. 1998;41(5):361-9.

2. Pang B, et al. Nat Commun. 2013;4:1908.

3. Nitiss JL. Nat Rev Cancer. 2009 May;9(5):338-50.

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